Estrogen replacement is a form of hormone therapy that increases levels of estrogen hormones in the body. It is used to treat common symptoms of menopause and aging among women, such as hot flashes, vaginal dryness, and sleep disturbance. Estrogen replacement may also help prevent bone density loss associated with menopause.

It may be prescribed during or after the menopause. Estrogen replacement comes in a variety of different forms, including patches, tablets, creams, injections, and suppositories. Drug classes commonly prescribed as part of estrogen replacement therapy include estrogens, excluding hormonal contraceptives, and estrogen and progestin combinations.