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Hypophosphatemia

Hypophosphatemia

Hypophosphatemia refers to a deficiency of phosphates in the blood. There are two kinds of hypophosphatemia; acute hypophosphatemia, which comes on quickly; and chronic hypophosphatemia, which manifests over a longer period of time. Familial hypophosphatemia is a rare inherited condition that may lead to rickets and osteomalacia.

Hypophosphatemia is rarely caused by a dietary deficiency as potassium is found in many foods. It is more likely to be caused by an underlying medical condition, such as diabetic ketoacidosis, kidney disorders, hyperparathyroidism, chronic diarrhea, or a vitamin D deficiency. Other possible causes include severe malnutrition, alcoholism, severe burns, and certain medications, such as diuretics, some hormones, and bisphosphonates. 

Mild cases of hypophosphatemia are often asymptomatic, but if phosphate levels drop to a particularly low level, signs may start to appear. These include fatigue, muscle weakness, loss of appetite, bone pain, bone fractures, irritability, numbness, and confusion. 

Treatment of hypophosphatemia usually involves addressing the underlying medical conditions or other causes. Severe cases may require treatment with intravenous phosphates. Medication and dietary supplements may also be prescribed, such as vitamin D supplements and potassium supplements.

Drugs Used To Treat Hypophosphatemia:



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The US Food and Drug Administration (FDA) has approved Crysvita (burosumab) as a treatment for a rare form of inherited rickets. It is the first drug therapy approved as a treatment for x-linked hypophosphatemia (XLH) with evidence of bone disease in children over one year of age and adolescents...

Read More... Apr 18, 2018