Iron overload, also known as hemochromatosis, refers to excessive levels of iron in the body. Excess iron may lead to other health complications, including liver disease, diabetes, and heart problems. 

Primary hemochromatosis is an inherited condition that affects an estimated one million people in the United States. Secondary hemochromatosis occurs as a result of other factors. These include medical conditions such as certain kinds of anemia, liver disease, or frequent blood transfusions.  

Symptoms of iron overload include weight loss, joint pain, abdominal pain or discomfort, fatigue, and weakness. Later symptoms of hemochromatosis include impotence, loss of sex drive, diabetes, heart failure, and liver failure. 

Treatment of iron overload generally involves lowering iron levels. Drug classes often prescribed to treat the condition are certain chelating agents, such as antidotes, systemic.