Haegarda, the first subcutaneous preventative treatment for patients with hereditary angioedema (HAE), is now available in American pharmacies. The drug, developed by pharmaceutical giant CSL Behring, was approved for routine prophylaxis to prevent HAE attacks in adults and adolescents by the US...
Read More... Jul 31, 2017Hereditary Angioedema
Hereditary angioedema is a rare inherited blood disorder that causes swelling beneath the skin. It is caused by an imbalance of the C1 inhibitor protein, which leads to a build-up of fluid and swelling. It can affect different parts of the body but may be more common in the mouth, throat, face, hands, feet, genitals, and stomach.
Symptoms usually first manifest during childhood and include swelling, fatigue, muscle ache, headaches, hoarseness, mood changes and a tingling sensation. Hereditary angioedema may be triggered by stress and anxiety; injuries, surgery or trauma; certain illnesses, such as the flu; physical activity; and certain medications.
There is no cure for hereditary angioedema, but symptoms may be alleviated with treatment and medication. Management of the condition involves preventing further attacks and treating attacks if they do occur. Depending on the severity of the attack and the part of the body affected, intravenous fluids and airway support may be needed.
Drug classes commonly prescribed to treat hereditary angioedema include blood coagulation factors, inhibitors of the kallikrein-kinin-system, and other cardiovascular products.
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